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J Clin Microbiol. 2013 Oct;51(10):3418-20. doi: 10.1128/JCM.01359-13. Epub 2013 Jul 31.

Comparison of the FDA-approved CDC DENV-1-4 real-time reverse transcription-PCR with a laboratory-developed assay for dengue virus detection and serotyping.

Author information

1
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Dengue virus (DENV) is the agent of the most common vector-borne disease worldwide. Using 199 clinical samples collected from Nicaragua and Sri Lanka, a laboratory-developed DENV multiplex real-time reverse transcription-PCR (rRT-PCR) proved more clinically sensitive than the FDA-approved CDC assay for DENV serotypes 1 to 4 when measured against a composite reference standard, with sensitivities of 97.4% versus 87.1%, respectively.

PMID:
23903549
PMCID:
PMC3811623
DOI:
10.1128/JCM.01359-13
[Indexed for MEDLINE]
Free PMC Article

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