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J Infect Dis. 2013 Nov 15;208(10):1664-8. doi: 10.1093/infdis/jit348. Epub 2013 Jul 29.

Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.

Author information

1
Section of Paediatrics.

Abstract

We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.

KEYWORDS:

Peptide Chain Initiation; RSV; eIF-2 Kinase; gene expression profiling; influenza; microarray analysis; pediatric; respiratory tract infection

PMID:
23901082
PMCID:
PMC3805235
DOI:
10.1093/infdis/jit348
[Indexed for MEDLINE]
Free PMC Article

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