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Biochem Biophys Res Commun. 1990 Aug 16;170(3):1365-70.

Mycoplasma can enhance HIV replication in vitro: a possible cofactor responsible for the progression of AIDS.

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Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.


Mycoplasma membrane protein (MMP) augmented HIV production from MOLT-4 cells chronically infected by HIV. A nearly 3-fold increase of HIV p24 antigen was detected in MMP-treated culture as compared to control culture at 100 micrograms/ml. MMP also augmented HIV production in different T cells chronically infected by HIV-1 and ARV-1. Kinetic experiment showed that HIV production was maximally elevated 24 hr after exposure to MMP. Similarly, MMP also augmented HIV-induced cell fusion and virus production in coculture. Hybridization experiment revealed that this augmentation was due to enhancement of HIV transcription.

[Indexed for MEDLINE]

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