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Nat Rev Neurosci. 2013 Sep;14(9):638-48. doi: 10.1038/nrn3546. Epub 2013 Jul 31.

Proteostasis in complex dendrites.

Author information

1
The Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany.

Abstract

Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ∼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage and plastic properties. The cell biological mechanisms that synthesize, modify, deliver and degrade dendritic and synaptic proteins are not well understood but appear to reflect unique solutions adapted to the particular morphology of neurons.

PMID:
23900412
DOI:
10.1038/nrn3546
[Indexed for MEDLINE]

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