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Am J Pathol. 2013 Oct;183(4):1052-1063. doi: 10.1016/j.ajpath.2013.04.033. Epub 2013 Jul 27.

Epigenetic modifications in breast cancer and their role in personalized medicine.

Author information

1
Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
2
Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain; Catalonian Institute for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address: mesteller@idibell.cat.

Abstract

In cancer, the overall patterns of epigenetic marks are severely distorted from the corresponding normal cell type. It is now well established that these changes can contribute to cancer development through inactivation of tumor suppressor genes and, conversely, through activation of oncogenes. Recent technological advances have enabled epigenome-wide analyses of cancers that are yielding unexpected findings. The study of cancer epigenetics holds great promise for expanding the range of therapeutic opportunities for personalized medicine. Here, we focus on DNA methylation in breast cancer and the potential implications for clinical management of patients.

PMID:
23899662
DOI:
10.1016/j.ajpath.2013.04.033
[Indexed for MEDLINE]
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