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Chemistry. 2013 Aug 26;19(35):11502-6. doi: 10.1002/chem.201302107. Epub 2013 Jul 29.

A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities.

Author information

1
Department of Organic Chemistry, Indian Association for the Cultivation of Science Jadavpur, Kolkata 700032, India.

Abstract

Like likes like! A novel fluorescent C2 -symmetric guanosine-based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells.

KEYWORDS:

G-quadruplex DNA; cell cycles; click chemistry; fluorescence; nucleosides

PMID:
23897752
DOI:
10.1002/chem.201302107
[Indexed for MEDLINE]
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