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Org Biomol Chem. 2013 Sep 25;11(40):6929-33. doi: 10.1039/c3ob40495a.

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor.

Author information

1
Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul, South Korea. enzymo@yonsei.ac.kr.

Abstract

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

PMID:
23897436
DOI:
10.1039/c3ob40495a
[Indexed for MEDLINE]
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