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EMBO Rep. 2013 Sep;14(9):788-94. doi: 10.1038/embor.2013.114. Epub 2013 Jul 30.

Casein kinase 2 is essential for mitophagy.

Author information

1
Laboratory of Biosignaling, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510.

Abstract

Mitophagy is a process that selectively degrades mitochondria. When mitophagy is induced in yeast, the mitochondrial outer membrane protein Atg32 is phosphorylated, interacts with the adaptor protein Atg11 and is recruited into the vacuole with mitochondria. We screened kinase-deleted yeast strains and found that CK2 is essential for Atg32 phosphorylation, Atg32-Atg11 interaction and mitophagy. Inhibition of CK2 specifically blocks mitophagy, but not macroautophagy, pexophagy or the Cvt pathway. In vitro, CK2 phosphorylates Atg32 at serine 114 and serine 119. We conclude that CK2 regulates mitophagy by directly phosphorylating Atg32.

PMID:
23897086
PMCID:
PMC3790056
DOI:
10.1038/embor.2013.114
[Indexed for MEDLINE]
Free PMC Article

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