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Int J Mol Sci. 2013 Jul 26;14(8):15636-54. doi: 10.3390/ijms140815636.

Exploring the glycosylation of serum CA125.

Author information

1
NIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Mount Merrion, Blackrock, Dublin 4, Ireland. radka.fahey@nibrt.ie

Abstract

Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls. We found differences between CA125 N-glycans from patient sera compared to controls. These include increases in core-fucosylated bi-antennary monosialylated glycans, as well as decreases in mostly bisecting bi-antennary and non-fucosylated glycans in patients compared to controls. Measurement of the glycosylated state of CA125 may therefore provide a more specific biomarker for patients with ovarian cancer.

PMID:
23896595
PMCID:
PMC3759877
DOI:
10.3390/ijms140815636
[Indexed for MEDLINE]
Free PMC Article

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