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J Pediatr. 2013 Nov;163(5):1503-6.e1. doi: 10.1016/j.jpeds.2013.06.025. Epub 2013 Jul 26.

Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates.

Author information

1
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Abstract

Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.

KEYWORDS:

AGA; Appropriate for gestational age; BW; Birth weight; COL4A1; Collagen 4A1; Gr; Grade; IL; IVH; Interleukin; Intraventricular hemorrhage; MTHFR; Methylenetetrahydrofolate reductase; TNF; Tumor necrosis factor

PMID:
23896193
PMCID:
PMC3812267
DOI:
10.1016/j.jpeds.2013.06.025
[Indexed for MEDLINE]
Free PMC Article

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