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Hand Clin. 2013 Aug;29(3):331-48. doi: 10.1016/j.hcl.2013.04.003.

Nerve allografts and conduits in peripheral nerve repair.

Author information

1
Department of Orthopaedic Surgery, University of California Irvine, 2226 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA.

Abstract

Since the last update on nerve conduits and allograft in 2000, investigations have established the efficacy of these alternatives to autograft in the repair of small sensory neural gaps. However, limited insights into the biology of the regenerating nerve continue to preclude intelligent conduit design. Ongoing discoveries in neuroscience and biomaterial engineering hold promise for the eventual development of allograft and conduits with potential of surpassing nerve autografts in clinical efficacy. In this review, we summarize the history, recent advances, and emerging developments in nerve conduits and allograft.

KEYWORDS:

Allograft; Nerve conduit; Peripheral nerve injury; Peripheral nerve repair

PMID:
23895714
DOI:
10.1016/j.hcl.2013.04.003
[Indexed for MEDLINE]
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