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Dermatol Surg. 2013 Oct;39(10):1452-8. doi: 10.1111/dsu.12268. Epub 2013 Jul 29.

Clinical improvement of striae distensae in Korean patients using a combination of fractionated microneedle radiofrequency and fractional carbon dioxide laser.

Author information

1
Department of Dermatology, Keimyung University School of Medicine, Daegu, South Korea.

Abstract

BACKGROUND:

Striae distensae are dermal scars with flattening and atrophy of the epidermis.

OBJECTIVE:

To evaluate the efficacy and safety of combination therapy with fractionated microneedle radiofrequency (RF) and fractional carbon dioxide (CO2) laser in the treatment of striae distensae.

MATERIALS AND METHODS:

Thirty patients (30 female; mean age 33, range 21-51, Fitzpatrick skin type IV) with moderate to severe striae distensae were enrolled in this study. Patients were divided into three groups: fractional CO2 laser only (n = 10), microneedle RF only (n = 10), and combination (n = 10).

RESULTS:

Improvement was evaluated using a visual analogue scale (range 1-4). Mean clinical improvement score of the dermatologist was 2.2 in the fractional CO2 laser-treated group, 1.8 in the microneedle RF-treated group, and 3.4 in the combination group. Through skin biopsy, we observed thickened epidermis and a clear increase in the number of collagen fibers in the microneedle RF- and fractional CO2 combination-treated sites. Consistent with these results, greater expression of transforming growth factor-β1 and stratifin was observed in treated sites.

CONCLUSION:

Combination therapy of fractionated microneedle RF and fractional CO2 laser is a safe treatment protocol with a positive therapeutic effect on striae distensae.

PMID:
23895146
DOI:
10.1111/dsu.12268
[Indexed for MEDLINE]

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