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Oncoimmunology. 2013 Jun 1;2(6):e24440. Epub 2013 May 14.

Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy.

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Department of Tumor Immunology; Nijmegen Centre for Molecular Life Sciences; Radboud University Nijmegen Medical Centre; Nijmegen, the Netherlands.


Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.


cancer immunotherapy; dendritic cell vaccination; helper T cells; metastatic melanoma

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