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Oncoimmunology. 2013 Jun 1;2(6):e24438. Epub 2013 May 8.

ATM activation mediates anticancer immunosurveillance by natural killer and T cells.

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Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.


The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhanced immune recognition by stimulating the expression of the DNAM-1 ligand CD155.


DNA damage response; DNAM-1 ligand; T cells; immunosurveillance; natural killer cells

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