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Oncoimmunology. 2013 Jun 1;2(6):e24384. Epub 2013 May 10.

A self antigen reopens the games in pancreatic cancer.

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Center for Experimental Research and Medical Studies (CERMS); Città della Salute e della Scienza di Torino; University of Torino; Torino, Italy ; Department of Molecular Biotechnology and Health Sciences; University of Torino; Torino, Italy.


We have recently demonstrated that the administration of a plasmid coding for α-enolase can elicit robust immune responses in genetically engineered mice that spontaneously develop pancreatic cancer, resulting in a significant improvement of their survival. This approach provides a springboard for the elaboration of new forms of immunotherapy for pancreatic cancer.


DNA vaccination; cancer immunotherapy; mouse models; pancreatic cancer; α-enolase

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