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PLoS One. 2013 Jul 24;8(7):e69341. doi: 10.1371/journal.pone.0069341. Print 2013.

Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes.

Author information

1
Maternal Fetal Medicine Department, Hospital Clinic, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. tcobo@clinic.ub.es

Abstract

OBJECTIVE:

To evaluate umbilical cord interleukin (IL)-6 and funisitis as independent predictors of early-onset neonatal sepsis (EONS) in preterm prelabor rupture of membranes (PPROM).

DESIGN:

Prospective cohort study.

SETTING:

Evaluation of umbilical cord IL-6 and funisitis as predictors of early-onset neonatal sepsis in PPROM.

POPULATION:

176 women with PPROM between 23+0-36+6 weeks of gestation.

METHODS:

Umbilical cord IL-6 was assayed by ELISA. Funisitis was defined according to the Salafia classification. Data was adjusted by gestational age at delivery and prenatal administration of corticosteroids and antibiotics.

MAIN OUTCOME MEASURES:

Binary logistic regression was performed to assess the independence of umbilical cord IL-6 and funisitis to predict EONS in women complicated with PPROM.

RESULTS:

The rate of EONS was 7%. Funisitis was present in 18% of women. Umbilical cord IL-6 was significantly higher in women complicated with EONS than without [median (range) 389.5 pg/mL (13.9-734.8) vs 5.2 (0.1-801-4), p<0.001]. Umbilical cord IL-6 was the only independent predictor of early-onset neonatal sepsis (odds ratio 13.6, p = 0.004).

CONCLUSION:

Umbilical cord IL-6 was the only predictor of early-onset neonatal sepsis in PPROM. Contrary to what is reported, funisitis was not.

PMID:
23894452
PMCID:
PMC3722235
DOI:
10.1371/journal.pone.0069341
[Indexed for MEDLINE]
Free PMC Article
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