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Mol Nutr Food Res. 2013 Nov;57(11):2075-8. doi: 10.1002/mnfr.201300054. Epub 2013 Jul 26.

Okra polysaccharide improves metabolic disorders in high-fat diet-induced obese C57BL/6 mice.

Author information

1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.

Abstract

Okra is a tropical vegetable that is rich in polysaccharides. Here, we investigated the effects of okra polysaccharide (OP) on metabolic disorders in mice. We found that OP lowered body weight and glucose levels, improved glucose tolerance, and decreased serum total cholesterol levels in high-fat diet-fed C57BL/6 mice. OP regulated the gene expression of liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) and their target genes in the liver and the adipose tissue of the mice. These results suggest that OP may have therapeutic effects on metabolic diseases via the inhibition of LXR and PPAR signaling.

KEYWORDS:

Diabetes; Hyperlipidemia; Metabolic syndrome; Okra; Polysaccharide

PMID:
23894043
DOI:
10.1002/mnfr.201300054
[Indexed for MEDLINE]
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