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Nat Genet. 2013 Aug;45(8):846-7. doi: 10.1038/ng.2709.

A new player SETs in myeloid malignancy.

Abstract

Recent studies have identified recurrent mutations in SETBP1, the gene that encodes SET-binding protein 1, in several types of myeloid malignancies, including chronic myeloid and acute myeloid leukemias. The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.

PMID:
23892662
PMCID:
PMC4310681
DOI:
10.1038/ng.2709
[Indexed for MEDLINE]
Free PMC Article

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