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Vasc Med. 2013 Aug;18(4):204-14. doi: 10.1177/1358863X13499773. Epub 2013 Jul 26.

Endothelial microparticles: sophisticated vesicles modulating vascular function.

Author information

1
Trinity Biomedical Science Institute (TBSI), Dublin, Ireland. acurtis@tcd.ie

Abstract

Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.

KEYWORDS:

endothelial dysfunction; endothelial microparticles; therapeutics; vesiculation

PMID:
23892447
PMCID:
PMC4437568
DOI:
10.1177/1358863X13499773
[Indexed for MEDLINE]
Free PMC Article

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