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Immunol Lett. 2013 Jun;153(1-2):50-7. doi: 10.1016/j.imlet.2013.07.004. Epub 2013 Jul 23.

Chloroquine: modes of action of an undervalued drug.

Author information

1
Department of Structural and Functional Biology, Institute of Biology, University of Campinas--UNICAMP, São Paulo, Brazil. rodolfo.thome@gmail.com

Abstract

For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results. In this review, we discuss recent findings and CQ mechanisms of action vis-à-vis its use as a broad adjunct therapy.

KEYWORDS:

Autoimmunity; Chloroquine; Malaria; Transplantation

PMID:
23891850
DOI:
10.1016/j.imlet.2013.07.004
[Indexed for MEDLINE]

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