Format

Send to

Choose Destination
See comment in PubMed Commons below
Radiother Oncol. 2013 Aug;108(2):232-5. doi: 10.1016/j.radonc.2013.06.030. Epub 2013 Jul 25.

Equivalent uniform dose for accelerated partial breast irradiation using the MammoSite applicator.

Author information

1
St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, United Kingdom. Electronic address: Alexandra.stewart@nhs.net.

Abstract

INTRODUCTION:

This study aims to quantify the radiobiology of the MammoSite applicator and examine whether there is a relationship between equivalent uniform dose (EUD) and radiotherapy-associated toxicity.

METHODS AND MATERIALS:

A previously-published version of the linear quadratic (LQ) model, designed to address the impact of dose-gradients in brachytherapy applications, was used to determine the biological effective dose (BED), equivalent dose in 2 Gray per fraction (EQD2) and EUD for the most common fractionation scheme for the MammoSite catheter (34 Gy in 10 fractions prescribed to 1cm from the balloon surface), using a range of balloon sizes in a series of patients treated with single or multiple dwell positions. Toxicity from the MammoSite catheter was assessed and statistical associations with the calculated EUDs were investigated.

RESULTS:

The acute- and late-toxicity EUDs respectively range from 34.8-39.4 Gy and 33.4-37.6 Gy, with EUD decreasing as balloon diameter increases and/or the number of dwell positions increases. There was a positive association between EUD and hyperpigmentation and telangiectasia.

CONCLUSIONS:

For APBI using the Mammosite applicator, EUD is higher than the marginal prescription dose and, for the dose-fractionation patterns considered here, was associated with acute and late skin toxicity. EUD is a potentially useful parameter to characterize non-uniform dose distributions related to brachytherapy treatments. Further evaluation in future studies is warranted.

KEYWORDS:

Equivalent uniform dose; MammoSite catheter; Radiobiology; Toxicity analysis

PMID:
23891101
DOI:
10.1016/j.radonc.2013.06.030
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center