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Cell. 2013 Aug 1;154(3):479-81. doi: 10.1016/j.cell.2013.07.008. Epub 2013 Jul 25.

Just a trim, please: refining ER degradation through deubiquitination.

Author information

1
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. jbrodsky@pitt.edu

Abstract

ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.

PMID:
23890819
PMCID:
PMC5423715
DOI:
10.1016/j.cell.2013.07.008
[Indexed for MEDLINE]
Free PMC Article

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