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Curr Opin Cell Biol. 2013 Dec;25(6):724-9. doi: 10.1016/j.ceb.2013.07.002. Epub 2013 Jul 24.

Metabolic regulation of the cell cycle.

Author information

1
Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11-1 Daehyun-Dong Seodaemoon-Gu, Seoul, South Korea.

Abstract

There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore the recent progress in this area with particular emphasis on how nutrient and energetic status is sensed within the cell to ultimately regulate cell growth and division. The role these pathways play in normal cell function including stem cell biology is also discussed. Furthermore, we describe the growing appreciation that dysregulation of these pathways might contribute to a variety of pathological conditions including metabolic diseases and tumor formation.

PMID:
23890700
PMCID:
PMC3836844
DOI:
10.1016/j.ceb.2013.07.002
[Indexed for MEDLINE]
Free PMC Article

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