Cyclotron Production of (99m)Tc using (100)Mo2C targets

Nucl Med Biol. 2013 Oct;40(7):939-45. doi: 10.1016/j.nucmedbio.2013.06.005. Epub 2013 Jul 23.

Abstract

An investigative study of the (100)Mo (p,2n)(99m)Tc reaction on a medical cyclotron using (100)Mo2C is reported. This is the first report of this compound being used as a target for this reaction. (100)Mo2C, a refractory carbide with high thermal conductivity, properties which underscore its use on a cyclotron, was synthesized using (100)MoO3. Its ease of oxidation back to (100)MoO3 under air at elevated temperatures facilitates the use of thermo-chromatography, a high temperature gas phase separation technique for the separation and isolation of (99m)Tc. Activity yields for (99m)Tc averaged 84% of the calculated theoretical yields. Additionally, the percent recovery of MoO3, the precursor for Mo2C, was consistently high at 85% ensuring a good life cycle for this target material. The produced (99m)Tc was radio-chemically pure and easily labeled MDP for imaging purposes.

Keywords: (99m)Tc; Cyclotron; Mo(2)C; Thermochromatography.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cyclotrons*
  • Isotopes / chemistry
  • Mice
  • Molybdenum / chemistry*
  • Radiochemistry / instrumentation*
  • Technetium / chemistry*
  • Technetium Tc 99m Medronate / chemistry
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Isotopes
  • molybdenum carbide
  • Technetium
  • Molybdenum
  • Technetium Tc 99m Medronate