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Am J Infect Control. 2013 Dec;41(12):1231-5. doi: 10.1016/j.ajic.2013.04.005. Epub 2013 Jul 23.

Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk: a multicenter, double-blinded, randomized comparative study in users of day care facilities for the elderly population.

Author information

1
Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan; Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: retsu-tky@umin.ac.jp.

Abstract

BACKGROUND:

There is insufficient evidence of preventive effect of probiotics on upper respiratory tract infections (URTIs) in an elderly population.

METHODS:

We conducted a multicenter, double-blinded, randomized, placebo-controlled parallel group study. Elderly persons had participated who used day care at 4 facilities in Tokyo. We used fermented milks containing Lactobacillus casei strain Shirota (LcS) and placebo drinks as test drinks.

RESULTS:

A total of 154 subjects was analyzed. The number of persons diagnosed with an acute URTIs was almost identical in both groups (LcS: 31, placebo: 32), whereas the number of acute URTIs events (LcS: 68, placebo: 51) and the symptom score (LcS: 425, placebo: 396) were both higher in the LcS group. Permutation tests performed using the total number of acute URTIs infection events/total days of observation and the total symptom score/total days of observation found no statistically significant difference respectively (P values of .89 and .64, respectively). Comparing the mean duration of infection per infection event found a shorter mean duration in the LcS group (LcS: 3.71 days, placebo: 5.40 days), and the difference was statistically significant.

CONCLUSION:

The results suggest that fermented milk containing LcS probably reduces the duration of acute URTIs.

KEYWORDS:

Compromised host; Geriatric health services; Lactobacillus casei strain Shirota; Probiotics

PMID:
23890374
DOI:
10.1016/j.ajic.2013.04.005
[Indexed for MEDLINE]
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