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Curr Top Membr. 2013;71:33-58. doi: 10.1016/B978-0-12-407870-3.00002-0.

STIM-ORAI interactions that control the CRAC channel.

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La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.


The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.


CRAC channel; CRAC current; ORAI1; ORAI3; STIM1; calcium; gating; interaction; mutation; protein; store-operated calcium entry; structure

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