Format

Send to

Choose Destination
Neuron. 2013 Jul 24;79(2):281-92. doi: 10.1016/j.neuron.2013.05.015.

The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior.

Author information

1
Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

Abstract

The transcription factor Mef2 regulates activity-dependent neuronal plasticity and morphology in mammals, and clock neurons are reported to experience activity-dependent circadian remodeling in Drosophila. We show here that Mef2 is required for this daily fasciculation-defasciculation cycle. Moreover, the master circadian transcription complex CLK/CYC directly regulates Mef2 transcription. ChIP-Chip analysis identified numerous Mef2 target genes implicated in neuronal plasticity, including the cell-adhesion gene Fas2. Genetic epistasis experiments support this transcriptional regulatory hierarchy, CLK/CYC- > Mef2- > Fas2, indicate that it influences the circadian fasciculation cycle within pacemaker neurons, and suggest that this cycle also contributes to circadian behavior. Mef2 therefore transmits clock information to machinery involved in neuronal remodeling, which contributes to locomotor activity rhythms.

PMID:
23889933
PMCID:
PMC3859024
DOI:
10.1016/j.neuron.2013.05.015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center