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Anal Chem. 2013 Sep 3;85(17):8135-41. doi: 10.1021/ac401080u. Epub 2013 Aug 15.

Highly stable surface functionalization of microgas chromatography columns using layer-by-layer self-assembly of silica nanoparticles.

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Department of Physics, Virginia Tech, Blacksburg, Virginia 24061, USA.


A controllable and high-yield surface functionalization of silicon microchannels using layer-by-layer (LbL) self-assembly of SiO2 nanoparticles (SNPs) is presented. The application of SNPs (45 nm average diameter) coating as a stationary phase for chromatographic separation is also demonstrated with surface functionalization using chloroalkylsilanes. This method facilitates a simple, low-cost, and parallel processing scheme that also provides homogeneous and stable nanoparticle-based stationary phases with ease of control over the coating thickness. The SNP-functionalized microfabricated columns with either single capillary channels (1 m long, 150 μm wide, 240 μm deep) or very narrow multicapillary channels (25 cm long, 30 μm wide, 240 μm deep, 16 parallel channels) successfully separated a multicomponent gas mixture with a wide range of boiling points with high reproducibility.


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