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Contact Dermatitis. 2013 Oct;69(4):231-8. doi: 10.1111/cod.12123. Epub 2013 Jul 27.

Risk factors associated with methylisothiazolinone contact sensitization.

Author information

1
Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, 91054, Erlangen, Germany.

Abstract

BACKGROUND:

The preservative methylisothiazolinone (MI) has become an important allergen, with a dramatic increase in sensitization prevalence being seen over the last few years.

OBJECTIVE:

To examine risk factors associated with MI sensitization, in order to identify targets of prevention aimed at curtailing the present epidemic.

METHODS:

On the basis of contact allergy surveillance data collected by the Information Network of Departments of Dermatology (www.ivkd.org), 2009-2012, in the course of 28,922 patch tests with MI, 500 ppm in water, included in a series of cosmetic preservatives, logistic regression analysis was employed to quantify the risk associated with a number of putative risk factors.

RESULTS:

The prevalence of MI sensitization increased from 1.94% in 2009 to 6.02% in 2012, the increase being mainly driven by female patients aged≥ 40 years, patients with face dermatitis, and the use of cosmetics. Adjusted multifactorial analysis additionally identified several occupations (e.g. painters and beauticians) and ano-genital dermatitis as risk factors for MI sensitization.

CONCLUSIONS:

The present use concentrations of MI, both cosmetic and industrial, are too high; (self-)regulatory action is urgently needed. MI should be added to the baseline series.

KEYWORDS:

CAS 2682-20-4; clinical epidemiology; contact allergy; methylisothiazolinone

PMID:
23889333
DOI:
10.1111/cod.12123
[Indexed for MEDLINE]
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