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Neurobiol Learn Mem. 2014 Feb;108:172-84. doi: 10.1016/j.nlm.2013.07.014. Epub 2013 Jul 22.

An application of Pavlovian principles to the problems of obesity and cognitive decline.

Author information

1
American University, Washington, DC, United States. Electronic address: terryd@american.edu.
2
American University, Washington, DC, United States.
3
Purdue University, West Lafayette, IN, United States.

Abstract

An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regulation. Within our framework, this disruption occurs when (a) consumption of sweet-tasting, but low calorie or noncaloric, foods and beverages reduces the ability of sweet tastes to predict the postingestive caloric consequences of intake and (b) consuming diets high in saturated fat and sugar (a.k.a., Western diet) impairs hippocampal-dependent learning and memory processes that are involved with the use of interoceptive "satiety" signals to anticipate when food and eating are not followed by appetitive postingestive outcomes. The paper concludes with discussion of a "vicious-cycle" model which links obesity to cognitive decline.

KEYWORDS:

Dementia; Energy regulation; Hippocampus; Ingestive behavior; Learning; Western diet

PMID:
23887140
PMCID:
PMC3899105
DOI:
10.1016/j.nlm.2013.07.014
[Indexed for MEDLINE]
Free PMC Article

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