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Immunobiology. 2013 Nov;218(11):1411-5. doi: 10.1016/j.imbio.2013.06.002. Epub 2013 Jun 17.

Soluble human CD83 ameliorates lupus in NZB/W F1 mice.

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  • 1Department of Internal Medicine 3 and Institute of Clinical Immunology, Nikolaus-Fiebiger Center, University of Erlangen-Nuremberg, Erlangen, Germany; Department of Internal Medicine 3, University of Technology, Dresden, Germany.


In the present study we explored the immunomodulatory potential of prokaryotically expressed soluble CD83 in the treatment of murine lupus using the NZB/W F1 mouse model. Therefore female NZB/W F1 lupus mice were treated either with sCD83 or PBS for 4 weeks. sCD83 treated mice showed a significantly delayed onset of anti-dsDNA autoantibody production when compared with the control group. Importantly, during the treatment period with sCD83 none of the mice showed elevated levels of anti-dsDNA autoantibodies. In addition, NZB/W F1 mice which received sCD83 displayed lower concentrations of anti-histone IgG autoantibodies. Furthermore, there was no difference in total IgG antibodies, indicating a modulatory role for sCD83 in the production of self-reactive antibodies without decreasing total IgG. These results indicate that administration of sCD83 has profound immune-modulatory effects on the induction of autoantibodies in NZB/W F1 lupus mice and may thus be a promising approach to interfere with autoimmunity in SLE and other autoantibody-driven diseases.


ASCs; Anti-ds-DNA antibodies; B cell activating factor belonging to the TNF family; BAFF; CD83; DC; ELISA; ELISPOT; FACS; FCS; IgG; Immunomodulation; Lupus; NZB/W F1 mice; New Zealand Black and New Zealand White F1 mice; PBMC; SLE; Soluble human; antibody secreting cells; dendritic cells; double stranded DNA; dsDNA; enzyme-linked immune sorbent assay; enzyme-linked immune sorbent spot; fetal calf serum; fluorescence activated cell sorting; immunglobulin G; peripheral blood monocytes; systemic lupus erythematosus

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