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Curr Biol. 2013 Jul 22;23(14):R626-33. doi: 10.1016/j.cub.2013.06.019.

Three functions of cadherins in cell adhesion.

Author information

1
EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. maitre@embl.de

Abstract

Cadherins are transmembrane proteins that mediate cell-cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis. Here, we review the three major functions of cadherins in cell-cell contact formation and stability. Two of those functions lead to a decrease in interfacial tension at the forming cell-cell contact, thereby promoting contact expansion--first, by providing adhesion tension that lowers interfacial tension at the cell-cell contact, and second, by signaling to the actomyosin cytoskeleton in order to reduce cortex tension and thus interfacial tension at the contact. The third function of cadherins in cell-cell contact formation is to stabilize the contact by resisting mechanical forces that pull on the contact.

PMID:
23885883
PMCID:
PMC3722483
DOI:
10.1016/j.cub.2013.06.019
[Indexed for MEDLINE]
Free PMC Article

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