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Reprod Sci. 2014 Mar;21(3):381-5. doi: 10.1177/1933719113497286. Epub 2013 Jul 24.

Granulocyte colony-stimulating factor administration for infertile women with thin endometrium in frozen embryo transfer program.

Author information

1
1Department of Obstetrics and Gynecology, Reproductive Medicine Centre, Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.

Abstract

We aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) administration for infertile women with thin endometrium in frozen embryo transfer program. Among 59 infertile patients with thin endometrium (≤7 mm), 34 patients received uterine infusion of recombinant human G-CSF (100 μg/0.6 mL) on the day of ovulation or administration of progesterone or human chorionic gonadotropin, with 40 cycles defined as G-CSF group and 49 previous cycles as self-controlled group, and 25 patients refused, with 80 cycles defined as the control group. Higher proportion of induced cycles and lower proportion of natural cycles were observed in the G-CSF group, when compared to the self-controlled group or control group (P < .05). The cycle cancellation rate was, in descending order, 69.39% in self-controlled group, 48.75% in control group, and 17.50% in G-CSF group, with significant difference (P < .05). The implantation rate and clinical pregnancy rate per embryo transfer were similar in all the groups (P > .05). Our study fails to demonstrate that G-CSF has the potential to improve embryo implantation and clinical pregnancy rate of the infertile women with thin endometrium.

KEYWORDS:

frozen embryo transfer; granulocyte colony-stimulating factor; implantation; pregnancy rate; thin endometrium

PMID:
23885097
DOI:
10.1177/1933719113497286
[Indexed for MEDLINE]

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