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Lupus. 2013 Sep;22(10):1011-6. doi: 10.1177/0961203313498799. Epub 2013 Jul 24.

Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients.

Author information

1
Department of Rheumatology, Qilu Hospital, Shandong University, PR China. qiufeng_sdu@163.com

Abstract

OBJECTIVE:

This study aims to investigate expression of interleukin 12 (IL-12) family cytokines IL-12, IL-23, IL-27 and IL-35 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid (GC) treatment on their expression.

METHODS:

Plasma concentration of IL-12, IL-23, IL-27, IL-35, IL-6 and anti-double-stranded DNA (dsDNA) antibodies in 30 newly diagnosed severe SLE patients and 30 matched healthy subjects was measured by enzyme-linked immunosorbent assay. The correlation between the levels of IL-12 family cytokines and the levels of IL-6 or anti-dsDNA antibodies was analyzed by Spearman rank correlation.

RESULTS:

Significantly higher levels of plasma IL-12, IL-23, IL-27, IL-35, IL-6 and anti-dsDNA antibodies were observed in SLE patients compared with healthy controls (p < 0.05), and after prednisone treatment, the serum levels of IL-12 family cytokines decreased significantly. Moreover, serum levels of IL-12, IL-23, IL-27 and IL-35 were correlated with serum levels of IL-6 and anti-dsDNA antibodies in pre-treatment as well as post-treatment SLE patients.

CONCLUSIONS:

SLE patients have increased plasma levels of IL-12 family cytokines and GCs can downregulate the expression of them in SLE patients. Therefore, members of the IL-12 family may be involved in the pathophysiological process of SLE.

KEYWORDS:

IL-12; IL-6; Systemic lupus erythematosus; glucocorticoid

PMID:
23884985
DOI:
10.1177/0961203313498799
[Indexed for MEDLINE]
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