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Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5829-35. doi: 10.1167/iovs.13-11918.

Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness.

Author information

1
Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, USA.

Abstract

PURPOSE:

We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT).

METHODS:

Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.

RESULTS:

In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm).

CONCLUSIONS:

Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.

KEYWORDS:

FECD; corneal endothelial cells; smoking

PMID:
23882692
PMCID:
PMC3755540
DOI:
10.1167/iovs.13-11918
[Indexed for MEDLINE]
Free PMC Article
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