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J Mol Biol. 1990 Aug 5;214(3):613-7.

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins.

Author information

1
Department of Chemistry, University of Cambridge, U.K.

Abstract

Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues.

PMID:
2388258
DOI:
10.1016/0022-2836(90)90275-Q
[Indexed for MEDLINE]

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