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Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a013060. doi: 10.1101/cshperspect.a013060.

Replication proteins and human disease.

Author information

1
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

Abstract

In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.

PMID:
23881941
PMCID:
PMC3941220
DOI:
10.1101/cshperspect.a013060
[Indexed for MEDLINE]
Free PMC Article

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