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Eur Radiol. 2014 Jan;24(1):12-8. doi: 10.1007/s00330-013-2970-3. Epub 2013 Jul 24.

A new-generation, low-permeability flow diverting device for treatment of saccular aneurysms.

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  • 1Center of Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland.

Abstract

OBJECTIVES:

We report a preclinical comparative study of a 96-strand braided flow diverter.

METHODS:

The 96-strand braided device was compared with the currently commercially available flow diverter with 48 strands. The devices were implanted across the neck of 12 elastase-induced aneurysms in New Zealand White rabbits and followed for 1 and 3 months (n = 6 respectively). Aneurysm occlusion rates, parent artery stenosis and patency of jailed branch occlusions were assessed by angiography, histology and scanning electron microscopy studies.

RESULTS:

It was feasible to navigate and implant the 96-strand device over the aneurysm orifice in all cases. At follow-up two aneurysms in the 48-strand vs. one in the 96-strand group were not occluded. This aneurysm from the 96-strand group however had a tracheal branch arising from the sac and showed a reverse remodelling of the vascular pouch at 3 months. In the occluded aneurysms, the parent artery was always completely reconstructed and the aneurysm orifice was sealed with neointimal tissue. No in-stent stenosis or jailed branch artery occlusion was observed.

CONCLUSIONS:

The 96-strand flow diverter proved to be safe, biocompatible and haemodynamically effective, induced stable occlusion of aneurysms and led to reverse remodelling of the parent artery.

KEY POINTS:

• Flow diversion has been introduced to improve endovascular treatment of cerebral aneurysms • A new low-permeability flow diverter is feasible for parent artery reconstruction. • The Silk 96 flow diverter appears effective at inducing aneurysm healing. • The covered branches remained patent at follow-up.

PMID:
23881302
DOI:
10.1007/s00330-013-2970-3
[PubMed - indexed for MEDLINE]
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