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Curr Opin Cell Biol. 2013 Oct;25(5):532-7. doi: 10.1016/j.ceb.2013.06.007. Epub 2013 Jul 20.

Gradient sensing during chemotaxis.

Author information

1
Chemotaxis Signal Section, Laboratory of Immunogenetics, NIAID, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, United States. tjin@niaid.nih.gov

Abstract

Eukaryotic cells have the ability to sense chemoattractant gradients and to migrate toward the sources of attractants. The chemical gradient-guided cell movement is referred to as chemotaxis. Chemoattractants are detected by members of G-protein-coupled receptors (GPCRs) that link to heterotrimeric G-proteins. The GPCR/G-protein sensing machinery is able to translate external chemoattractants fields into intercellular cues, which direct reorganization of the actin cytoskeleton that drives cell movement. Here, I review our current understanding of the formation of chemoattractant gradients in vivo, the GPCR-mediated gradient sensing, and the sophisticated signaling network that guides the function of the actin cytoskeleton.

PMID:
23880435
DOI:
10.1016/j.ceb.2013.06.007
[Indexed for MEDLINE]

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