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Am J Vet Res. 2013 Aug;74(8):1084-90. doi: 10.2460/ajvr.74.8.1084.

Effect of furosemide and high-dosage pimobendan administration on the renin-angiotensin-aldosterone system in dogs.

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  • 1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.

Abstract

OBJECTIVE:

To determine whether a high dosage of pimobendan, when administered concurrently with moderate-dosage furosemide to healthy dogs, would activate the renin-angiotensin-aldosterone system (RAAS) more than furosemide alone.

ANIMALS:

12 healthy dogs.

PROCEDURES:

6 dogs received furosemide (2.0 mg/kg, PO, q 12 h) only, as an RAAS activator, for 10 days. The other 6 dogs received furosemide (2.0 mg/kg, PO, q 12 h) and pimobendan (0.6 mg/kg, PO, q 12 h) for 10 days. The effect of these drugs on the RAAS was determined by measurement of the aldosterone-to-creatinine ratio (A:C) in urine collected in the morning and evening of study days -2, -1, 1, 5, and 10.

RESULTS:

Although there was an increase in the urine A:C during the study period in both groups, it was significant only for dogs that received both drugs. The urine A:C only differed significantly between groups on day 1, at which time A:C was greater in the group that received both drugs.

CONCLUSIONS AND CLINICAL RELEVANCE:

High-dosage pimobendan administration neither substantially suppressed nor potentiated the RAAS when administered with furosemide in healthy dogs.

PMID:
23879846
DOI:
10.2460/ajvr.74.8.1084
[PubMed - indexed for MEDLINE]
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