Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis

Mohan K Balasubramanian; Evelyn Yaqiong Tao

doi:10.1083/jcb.201306152

Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis

J Cell Biol. 2013 Jul 22;202(2):187-9. doi: 10.1083/jcb.201306152.

Authors

Mohan K Balasubramanian¹, Evelyn Yaqiong Tao

Affiliation

¹ Temasek Life Sciences Laboratory, 2 Department of Biological Sciences, and 3 Mechanobiology Institute, National University of Singapore, Singapore 117604.

Abstract

In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201302001 and Atkins et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201301090) establish that precise activation and/or inactivation of Rho1 and Cdc42 GTPases is important for the correct order and successful completion of events downstream of actomyosin ring constriction in budding yeast.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cytokinesis*
Microtubule-Associated Proteins / metabolism*
Mitosis*
Saccharomyces cerevisiae Proteins / metabolism*
Saccharomycetales / enzymology*
cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / metabolism*
rho GTP-Binding Proteins / metabolism*

Substances

Cyk3 protein, S cerevisiae
Microtubule-Associated Proteins
Saccharomyces cerevisiae Proteins
RHO1 protein, S cerevisiae
cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
rho GTP-Binding Proteins