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Cell Res. 2013 Oct;23(10):1159-60. doi: 10.1038/cr.2013.96. Epub 2013 Jul 23.

New hope for therapy in neurodegenerative diseases.

Author information

  • 1Department of Neurology, University of Michigan, A. Alfred Taubman Medical Research Institute, Ann Arbor, MI 48109-2200, USA.

Abstract

The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders. Using cross-species genetic screens, Park et al. recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing protein ATXN1 and its subsequent toxicity in SCA1.

PMID:
23877406
PMCID:
PMC3790243
DOI:
10.1038/cr.2013.96
[PubMed - indexed for MEDLINE]
Free PMC Article
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