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Arch Pharm Res. 2014 Mar;37(3):399-403. doi: 10.1007/s12272-013-0185-4. Epub 2013 Jul 23.

Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.

Author information

1
Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam.

Abstract

Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.

PMID:
23877238
DOI:
10.1007/s12272-013-0185-4
[Indexed for MEDLINE]

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