Format

Send to

Choose Destination
Hum Immunol. 2013 Nov;74(11):1486-90. doi: 10.1016/j.humimm.2013.07.001. Epub 2013 Jul 19.

Moving beyond HLA: a review of nHLA antibodies in organ transplantation.

Author information

1
California Pacific Medical Center, Research Institute, San Francisco, CA, USA.

Abstract

Given the finite graft life expectancy of HLA identical organ transplants and the recognition of humoral graft injury in the absence of donor directed anti-HLA antibodies, the clinical impact of antibodies against non-HLA (nHLA) antigens in transplant injury is being increasingly recognized. The recognition of the impact of nHLA antigen discrepancies between donor and recipient on transplant outcomes is timely given the advances in rapid and lower cost sequencing methods that can soon provide complete maps of all recipient and donor HLA and nHLA mismatch data. In this review, we present a summary of recent reports evaluating the role of nHLA antibodies and their relevance to the field of organ transplantation.

PMID:
23876683
PMCID:
PMC5221517
DOI:
10.1016/j.humimm.2013.07.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center