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Nitric Oxide. 2013 Sep 1;33:81-2. doi: 10.1016/j.niox.2013.07.006. Epub 2013 Jul 20.

Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia.

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Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.


Preeclampsia (PE) is characterized by hypertension and proteinuria. It has been classified in early or late according to gestational age at the onset of disease. Endothelial dysfunction plays a crucial part in its pathogenesis. NO is a potent vasodilator and ADMA is its endogenous inhibitor. We have assessed maternal ADMA levels. ADMA were increased in early [0.66 μmol/L] versus late sPE [0.47 μmol/L] (P=0.001) and versus normotensive pregnant [0.48 μmol/L] (P=0.001). Our findings suggest that high ADMA levels in early sPE could compromise NO synthesis contributing to endothelial dysfunction, leading to impaired placentation and the onset of this disease.


ADMA; Nitric oxide; Nitric oxide synthase; Preeclampsia

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