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PLoS One. 2013 Jul 10;8(7):e68778. doi: 10.1371/journal.pone.0068778. Print 2013.

Lifelong caloric restriction increases working memory in mice.

Author information

1
Institute for Experimental Surgery, University of Rostock, Rostock, Germany. angela.kuhla@uni-rostock.de

Abstract

Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.

PMID:
23874758
PMCID:
PMC3707851
DOI:
10.1371/journal.pone.0068778
[Indexed for MEDLINE]
Free PMC Article

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