Rag1−/− mice were infected with L. braziliensis in the ear, and reconstituted with either WT or Prf−/− CD8+ T cells. (A) Ear thickness at the site of infection. (B) Representative images of leishmanial lesions at 5 weeks post infection. At 7 weeks post infection mice were euthanized and shown are: (C) parasite burden in the lesions; representative (D) contour plots and (E) bar graph of CD8+ T cell in the lesion (pregated on: Live/Singlets/CD45+/CD8β+ cells). Graphs are representative data from one of three independent experiments (n = 5). Rag1−/− mice were infected with L. braziliensis in the ear, and reconstituted with either WT, IFN-γ−/−, or IL-17−/− CD8+ T cells. (F,H) Ear thickness at the site of infection; (G,I) Parasite burden in the lesions at 7 weeks post infection. Data from one (F,G) experiment or one representative experiment of two (H,I) (n = 5) are presented. *p<0.05.