Format

Send to

Choose Destination
Genes Dev. 2013 Jul 15;27(14):1551-6. doi: 10.1101/gad.214585.113.

The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation.

Author information

1
Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

Abstract

The Drosophila male-specific lethal (MSL) dosage compensation complex increases transcript levels on the single male X chromosome to equal the transcript levels in XX females. However, it is not known how the MSL complex is linked to its DNA recognition elements, the critical first step in dosage compensation. Here, we demonstrate that a previously uncharacterized zinc finger protein, CLAMP (chromatin-linked adaptor for MSL proteins), functions as the first link between the MSL complex and the X chromosome. CLAMP directly binds to the MSL complex DNA recognition elements and is required for the recruitment of the MSL complex. The discovery of CLAMP identifies a key factor required for the chromosome-specific targeting of dosage compensation, providing new insights into how subnuclear domains of coordinate gene regulation are formed within metazoan genomes.

KEYWORDS:

Drosophila; chromatin; dosage compensation; zinc finger protein

PMID:
23873939
PMCID:
PMC3731544
DOI:
10.1101/gad.214585.113
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center