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Nucleus. 2013 Jul-Aug;4(4):298-314. doi: 10.4161/nucl.25751. Epub 2013 Jul 17.

The nuclear envelope LEM-domain protein emerin.

Author information

1
Department of Cell Biology; Johns Hopkins University School of Medicine; Baltimore, MD USA.

Abstract

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.

KEYWORDS:

Emery-Dreifuss muscular dystrophy; GAGE cancer-testis antigen; LEM-domain; Nestor-Guillermo progeria; O-GlcNAc transferase; barrier-to-autointegration factor; emerin; laminopathy; nuclear envelope; nucleoskeleton

PMID:
23873439
PMCID:
PMC3810338
DOI:
10.4161/nucl.25751
[Indexed for MEDLINE]
Free PMC Article

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