Format

Send to

Choose Destination
Nat Neurosci. 2013 Sep;16(9):1331-9. doi: 10.1038/nn.3464. Epub 2013 Jul 21.

Cellular mechanisms of brain state-dependent gain modulation in visual cortex.

Author information

1
Department of Neurology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.

Abstract

Visual cortical neurons fire at higher rates to visual stimuli during locomotion than during immobility, while maintaining orientation selectivity. The mechanisms underlying this change in gain are not understood. We performed whole-cell recordings from layer 2/3 and layer 4 visual cortical excitatory neurons and from parvalbumin-positive and somatostatin-positive inhibitory neurons in mice that were free to rest or run on a spherical treadmill. We found that the membrane potential of all cell types became more depolarized and (with the exception of somatostatin-positive interneurons) less variable during locomotion. Cholinergic input was essential for maintaining the unimodal membrane potential distribution during immobility, whereas noradrenergic input was necessary for the tonic depolarization associated with locomotion. Our results provide a mechanism for how neuromodulation controls the gain and signal-to-noise ratio of visual cortical neurons during changes in the state of vigilance.

PMID:
23872595
PMCID:
PMC3786578
DOI:
10.1038/nn.3464
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center